Time-resolved X-ray scattering and RNA folding.
نویسندگان
چکیده
Time-resolved small-angle X-ray scattering (SAXS) reports changes in the global conformation of macromolecules and is thus a valuable probe of structural transitions like RNA folding. Time-resolved SAXS has been applied to study folding of the Tetrahymena ribozyme. This chapter describes the methods that enable acquisition and analysis of time-resolved SAXS data and insights into RNA folding gained from these studies.
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عنوان ژورنال:
- Methods in enzymology
دوره 469 شماره
صفحات -
تاریخ انتشار 2009